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KMID : 0363220140520040269
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Korean Journal of Dermatology
2014 Volume.52 No. 4 p.269 ~ p.273
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A Case of Large Cell Lung Carcinoma with Rhabdoid Phenotype Presenting as Cutaneous Metastasis
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Seo Hyun-Min
Kim Jung-In
Kim Yoon-Hwan
Min Joon-Hong
Lee Seung-Jae
Park Ji-Hye
Kim Won-Serk
Lee Ga-Young
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Abstract
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Large cell carcinoma with a rhabdoid phenotype is very rare. We report the case of a 53-year-old man who presentedwith multiple nodules on the scalp, face, and trunk. A skin biopsy revealed large cell carcinoma with a rhabdoidphenotype throughout the dermis. Tumor cells had abundant cytoplasm, eccentric nuclei, and prominent nucleoliand did not adhere to each other. Immunohistochemical tests showed positive reactions for vimentin, epithelialmembrane antigen (EMA), and thyroid transcription factor-1 (TTF-1) and weakly focal reactions for pan-CK, CK7,and p63. Imaging studies and a percutaneous lung biopsy were performed and the results were consistent with alarge cell lung carcinoma with a rhabdoid phenotype. Based on these clinical and histopathological findings, weconcluded that his condition was a cutaneous metastasis from a large cell lung carcinoma with a rhabdoidphenotype, which occurs very rarely.
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KEYWORD
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Cutaneous metastasis, Large cell lung carcinoma with rhabdoid phenotype, Rhabdoid tumor
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